Tag: AFP

Neural Tube Defects

Defects of neural tube development are congenital anomalies with an estimated incidence of 1 in 2,000 live births. Formation of the neural tube is completed by 28 days of gestation, before most women are even aware that they are pregnant. Neural tube defects (NTDs) result from the failure of closure of the neural folds at [...]

September 17, 2011 More
Alpha-Fetoprotein Screening

Alpha-Fetoprotein Screening

The value of alpha-fetoprotein (AFP) in detecting neural tube defects was recognized over 30 years ago. AFP is a glycoprotein synthesized by the fetal yolk sac, gastrointestinal tract, and liver. When the fetal integument is not intact, markedly elevated levels of AFP occur in the amniotic fluid and maternal serum. Hence, elevated AFP levels are [...]

July 28, 2011 More